The IGH locus relocalizes to a “recombination compartment” in the perinucleolar region of differentiating B-lymphocytes

The immunoglobulin heavy chain (IGH) gene loci are subject to specific recombination events during B-cell differentiation including somatic hypermutation and class switch recombination which mark the end of immunoglobulin gene maturation in germinal centers of secondary lymph nodes. These two events...

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Publicado en:Oncotarget
Autores principales: Pichugin, Andrey, Iarovaia, Olga V., Gavrilov, Alexey, Sklyar, Ilya, Barinova, Natalja, Barinov, Aleksandr, Ivashkin, Evgeny, Caron, Gersende, Aoufouchi, Said, Razin, Sergey V., Fest, Thierry, Lipinski, Marc, Vassetzky, Yegor S
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2017
Materias:
Research Paper: Chromosome
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5522243/
https://ncbi.nlm.nih.gov/pubmed/28445143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16941
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