Homoharringtonine targets Smad3 and TGF-β pathway to inhibit the proliferation of acute myeloid leukemia cells

Homoharringtonine (HHT) has long and widely been used in China for the treatment of acute myeloid leukemia (AML), the clinical therapeutic effect is significant but the working mechanism is poorly understood. The purpose of this study is to screen the possible target for HHT with virtual screening a...

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Udgivet i:Oncotarget
Main Authors: Chen, Jian, Mu, Qitian, Li, Xia, Yin, Xiufeng, Yu, Mengxia, Jin, Jing, Li, Chenying, Zhou, Yile, Zhou, Jiani, Suo, Shanshan, Lu, Demin, Jin, Jie
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2017
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5522237/
https://ncbi.nlm.nih.gov/pubmed/28454099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16956
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