Homoharringtonine exhibits potent anti-tumor effect and modulates DNA epigenome in acute myeloid leukemia by targeting SP1/TET1/5hmC

Homoharringtonine, a plant alkaloid, has been reported to suppress protein synthesis and has been approved by the US Food and Drug Administration for the treatment of chronic myeloid leukemia. Here we show that in acute myeloid leukemia (AML), homoharringtonine potently inhibits cell growth/viabilit...

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Opis bibliograficzny
Wydane w:Haematologica
Główni autorzy: Li, Chenying, Dong, Lei, Su, Rui, Bi, Ying, Qing, Ying, Deng, Xiaolan, Zhou, Yile, Hu, Chao, Yu, Mengxia, Huang, Hao, Jiang, Xi, Li, Xia, He, Xiao, Zou, Dongling, Shen, Chao, Han, Li, Sun, Miao, Skibbe, Jennifer, Ferchen, Kyle, Qin, Xi, Weng, Hengyou, Huang, Huilin, Song, Chunxiao, Chen, Jianjun, Jin, Jie
Format: Artigo
Język:Inglês
Wydane: Ferrata Storti Foundation 2020
Hasła przedmiotowe:
Article
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6939512/
https://ncbi.nlm.nih.gov/pubmed/30975912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2018.208835
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