Homoharringtonine binds to and increases myosin‐9 in myeloid leukaemia

BACKGROUND AND PURPOSE: Homoharringtonine (HHT) is a natural alkaloid isolated from various Cephalotaxus species. HHT has been used to treat acute myeloid leukaemia (AML), chronic myeloid leukaemia (CML), chronic lymphocyte leukaemia and myelodysplastic syndromes. Although HHT inhibits protein synth...

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Vydáno v:Br J Pharmacol
Hlavní autoři: Zhang, Ting, Shen, Shuijie, Zhu, Zhijuan, Lu, Shasha, Yin, Xiufeng, Zheng, Jiang, Jin, Jie
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2015
Témata:
Research Papers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4813388/
https://ncbi.nlm.nih.gov/pubmed/26448459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13359
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