Inhibition of pH regulation as a therapeutic strategy in hypoxic human breast cancer cells

Hypoxic cancer cells exhibit resistance to many therapies. This study compared the therapeutic effect of targeting the pH regulatory proteins (CAIX, NHE1 and V-ATPase) that permit cancer cells to adapt to hypoxic conditions, using both 2D and 3D culture models. Drugs targeting CAIX, NHE1 and V-ATPas...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Meehan, James, Ward, Carol, Turnbull, Arran, Bukowski-Wills, Jimi, Finch, Andrew J., Jarman, Edward J., Xintaropoulou, Chrysi, Martinez-Perez, Carlos, Gray, Mark, Pearson, Matthew, Mullen, Peter, Supuran, Claudiu T., Carta, Fabrizio, Harrison, David J., Kunkler, Ian H., Langdon, Simon P.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5522111/
https://ncbi.nlm.nih.gov/pubmed/28476026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.17143
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