Eg5 inhibitor YL001 induces mitotic arrest and inhibits tumor proliferation

Eg5 is a kinesin spindle protein that controls chromosomal segregation in mitosis and is thus a critical drug target for cancer therapy. We report the discovery of a potent, selective inhibitor of Eg5 designated YL001. YL001 was obtained through shape similarity based virtual screening, and it bears...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Oncotarget
Auteurs principaux: Wang, Yufei, Wu, Xingyu, Du, Mufeng, Chen, Xi, Ning, Xianling, Chen, Hong, Wang, Siyuan, Liu, Jia, Liu, Zhenming, Li, Ridong, Fu, Ge, Wang, Chunguang, McNutt, Michael A., Zhou, Demin, Yin, Yuxin
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2017
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5522084/
https://ncbi.nlm.nih.gov/pubmed/28489567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.17207
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires