Eg5 inhibitor YL001 induces mitotic arrest and inhibits tumor proliferation

Eg5 is a kinesin spindle protein that controls chromosomal segregation in mitosis and is thus a critical drug target for cancer therapy. We report the discovery of a potent, selective inhibitor of Eg5 designated YL001. YL001 was obtained through shape similarity based virtual screening, and it bears...

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發表在:Oncotarget
Main Authors: Wang, Yufei, Wu, Xingyu, Du, Mufeng, Chen, Xi, Ning, Xianling, Chen, Hong, Wang, Siyuan, Liu, Jia, Liu, Zhenming, Li, Ridong, Fu, Ge, Wang, Chunguang, McNutt, Michael A., Zhou, Demin, Yin, Yuxin
格式: Artigo
語言:Inglês
出版: Impact Journals LLC 2017
主題:
Research Paper
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5522084/
https://ncbi.nlm.nih.gov/pubmed/28489567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.17207
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