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Synthesis and antitumor activity of novel 2, 3-didithiocarbamate substituted naphthoquinones as inhibitors of pyruvate kinase M2 isoform

The M2 isoform of pyruvate kinase (PKM2) is a potential antitumor therapeutic target. In this study, we designed and synthesised a series of 2, 3-didithiocarbamate substituted naphthoquinones as PKM2 inhibitors based on the lead compound 3k that we previously reported. Among them, compound 3f (IC(50...

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Detalhes bibliográficos
Publicado no:J Enzyme Inhib Med Chem
Main Authors: Ning, Xianling, Qi, Hailong, Li, Ridong, Jin, Yan, McNutt, Michael A., Yin, Yuxin
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6010099/
https://ncbi.nlm.nih.gov/pubmed/29185365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2017.1404591
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