HIV-1 tat protein stimulates transcription by binding to a U-rich bulge in the stem of the TAR RNA structure.

The HIV-1 trans-activator protein, tat, is an RNA binding protein with a high affinity for a U-rich bulge near the tip of the stem in the RNA stem-loop structure encoded by the trans-activation responsive region (TAR). A Scatchard analysis of tat binding has shown that the purified protein forms a o...

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Dettagli Bibliografici
Pubblicato in:EMBO J
Autori principali: Dingwall, C, Ernberg, I, Gait, M J, Green, S M, Heaphy, S, Karn, J, Lowe, A D, Singh, M, Skinner, M A
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 1990
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC552188/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2249668/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1990.tb07637.x
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