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Host Cell Interactions are a Significant Barrier to the Clinical Utility of Peptide Antibiotics

Despite longstanding promise and many known examples, antimicrobial peptides (AMPs) have failed, thus far, to impact human medicine. Based on the physical chemistry and mechanism of action of AMPs, we hypothesized that host cell interactions could contribute to loss of activity in vivo where host ce...

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Detaylı Bibliyografya
Yayımlandı:ACS Chem Biol
Asıl Yazarlar: Starr, Charles G., He, Jing, Wimley, William C.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2016
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5521815/
https://ncbi.nlm.nih.gov/pubmed/27797468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.6b00843
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