PKR activation and eIF2α phosphorylation mediate human globin mRNA splicing at spliceosome assembly

Short elements in mammalian mRNA can control gene expression by activating the RNA-dependent protein kinase PKR that attenuates translation by phosphorylating cytoplasmic eukaryotic initiation factor 2α (eIF2α). We demonstrate a novel, positive role for PKR activation and eIF2α phosphorylation in hu...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cell Res
Egile Nagusiak: Ilan, Lena, Osman, Farhat, Namer, Lise Sarah, Eliahu, Einav, Cohen-Chalamish, Smadar, Ben-Asouli, Yitzhak, Banai, Yona, Kaempfer, Raymond
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 2017
Gaiak:
Original Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5520854/
https://ncbi.nlm.nih.gov/pubmed/28374749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2017.39
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