A cis-acting element in the 3′-untranslated region of human TNF-α mRNA renders splicing dependent on the activation of protein kinase PKR
We report a role for the 3′-untranslated region in control of mRNA splicing and show that human TNF-α 3′ UTR harbors a cis-acting element that renders splicing of precursor transcripts dependent on activation of PKR, the RNA-activated protein kinase that phosphorylates eukaryotic initiation factor 2...
Guardat en:
| Publicat a: | Genes Dev |
|---|---|
| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Cold Spring Harbor Laboratory Press
1999
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC317206/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10617576/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.13.24.3280 |
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