A cis-acting element in the 3′-untranslated region of human TNF-α mRNA renders splicing dependent on the activation of protein kinase PKR

We report a role for the 3′-untranslated region in control of mRNA splicing and show that human TNF-α 3′ UTR harbors a cis-acting element that renders splicing of precursor transcripts dependent on activation of PKR, the RNA-activated protein kinase that phosphorylates eukaryotic initiation factor 2...

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Pubblicato in:	Genes Dev
Autori principali:	Osman, Farhat, Jarrous, Nayef, Ben-Asouli, Yitzhak, Kaempfer, Raymond
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Cold Spring Harbor Laboratory Press 1999
Soggetti:	Research Paper
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC317206/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10617576/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.13.24.3280
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