PKR activation and eIF2α phosphorylation mediate human globin mRNA splicing at spliceosome assembly

Short elements in mammalian mRNA can control gene expression by activating the RNA-dependent protein kinase PKR that attenuates translation by phosphorylating cytoplasmic eukaryotic initiation factor 2α (eIF2α). We demonstrate a novel, positive role for PKR activation and eIF2α phosphorylation in hu...

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Publicado en:Cell Res
Autores principales: Ilan, Lena, Osman, Farhat, Namer, Lise Sarah, Eliahu, Einav, Cohen-Chalamish, Smadar, Ben-Asouli, Yitzhak, Banai, Yona, Kaempfer, Raymond
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2017
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5520854/
https://ncbi.nlm.nih.gov/pubmed/28374749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2017.39
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