Ubiquitylation of MFHAS1 by the ubiquitin ligase praja2 promotes M1 macrophage polarization by activating JNK and p38 pathways

Sepsis is a systemic inflammation caused by infection. The balance between M1–M2 macrophage polarization has an essential role in the pathogenesis of sepsis. However, the exact mechanism underlying macrophage polarization is unclear. We previously showed that levels of malignant fibrous histiocytoma...

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Veröffentlicht in:Cell Death Dis
Hauptverfasser: Zhong, Jing, Wang, Huihui, Chen, Wankun, Sun, Zhirong, Chen, Jiawei, Xu, Yajun, Weng, Meilin, Shi, Qiqing, Ma, Duan, Miao, Changhong
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2017
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5520684/
https://ncbi.nlm.nih.gov/pubmed/28471450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.102
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