Proteolysis of MOB1 by the ubiquitin ligase praja2 attenuates Hippo signalling and supports glioblastoma growth

Human glioblastoma is the most frequent and aggressive form of brain tumour in the adult population. Proteolytic turnover of tumour suppressors by the ubiquitin–proteasome system is a mechanism that tumour cells can adopt to sustain their growth and invasiveness. However, the identity of ubiquitin–p...

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Main Authors: Lignitto, Luca, Arcella, Antonietta, Sepe, Maria, Rinaldi, Laura, Delle Donne, Rossella, Gallo, Adriana, Stefan, Eduard, Bachmann, Verena A., Oliva, Maria A., Tiziana Storlazzi, Clelia, L'Abbate, Alberto, Brunetti, Arturo, Gargiulo, Sara, Gramanzini, Matteo, Insabato, Luigi, Garbi, Corrado, Gottesman, Max E., Feliciello, Antonio
Formato: Artigo
Idioma:Inglês
Publicado: Nature Pub. Group 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3674242/
https://ncbi.nlm.nih.gov/pubmed/23652010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms2791
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