Praja1 E3 ubiquitin ligase promotes skeletal myogenesis through degradation of EZH2 upon p38α activation

Polycomb proteins are critical chromatin modifiers that regulate stem cell differentiation via transcriptional repression. In skeletal muscle progenitors Enhancer of zeste homologue 2 (EZH2), the catalytic subunit of Polycomb Repressive Complex 2 (PRC2), contributes to maintain the chromatin of musc...

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Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Consalvi, Silvia, Brancaccio, Arianna, Dall'Agnese, Alessandra, Puri, Pier Lorenzo, Palacios, Daniela
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2017
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5423270/
https://ncbi.nlm.nih.gov/pubmed/28067271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13956
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