Endogenous hepcidin and its agonist mediate resistance to selected infections by clearing non–transferrin-bound iron

The iron-regulatory hormone hepcidin is induced early in infection, causing iron sequestration in macrophages and decreased plasma iron; this is proposed to limit the replication of extracellular microbes, but could also promote infection with macrophage-tropic pathogens. The mechanisms by which hep...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Blood
Autori principali: Stefanova, Deborah, Raychev, Antoan, Arezes, Joao, Ruchala, Piotr, Gabayan, Victoria, Skurnik, Mikael, Dillon, Barbara J., Horwitz, Marcus A., Ganz, Tomas, Bulut, Yonca, Nemeth, Elizabeta
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2017
Soggetti:
Plenary Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5520472/
https://ncbi.nlm.nih.gov/pubmed/28465342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-03-772715
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