Hepcidin Protects against Lethal Escherichia coli Sepsis in Mice Inoculated with Isolates from Septic Patients

Iron is an essential micronutrient for most microbes and their hosts. Mammalian hosts respond to infection by inducing the iron-regulatory hormone hepcidin, which causes iron sequestration and a rapid decrease in the plasma and extracellular iron concentration (hypoferremia). Previous studies showed...

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Veröffentlicht in:Infect Immun
Hauptverfasser: Stefanova, Deborah, Raychev, Antoan, Deville, Jaime, Humphries, Romney, Campeau, Shelley, Ruchala, Piotr, Nemeth, Elizabeta, Ganz, Tomas, Bulut, Yonca
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2018
Schlagworte:
Host Response and Inflammation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6013672/
https://ncbi.nlm.nih.gov/pubmed/29735522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00253-18
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