Hepcidin Protects against Lethal Escherichia coli Sepsis in Mice Inoculated with Isolates from Septic Patients

Iron is an essential micronutrient for most microbes and their hosts. Mammalian hosts respond to infection by inducing the iron-regulatory hormone hepcidin, which causes iron sequestration and a rapid decrease in the plasma and extracellular iron concentration (hypoferremia). Previous studies showed...

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Detalhes bibliográficos
Publicado no:Infect Immun
Principais autores: Stefanova, Deborah, Raychev, Antoan, Deville, Jaime, Humphries, Romney, Campeau, Shelley, Ruchala, Piotr, Nemeth, Elizabeta, Ganz, Tomas, Bulut, Yonca
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Host Response and Inflammation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6013672/
https://ncbi.nlm.nih.gov/pubmed/29735522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00253-18
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