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Molecular design and synthesis of self-assembling camptothecin drug amphiphiles

The conjugation of small molecular hydrophobic anticancer drugs onto a short peptide with overall hydrophilicity to create self-assembling drug amphiphiles offers a new prodrug strategy, producing well-defined, discrete nanostructures with a high and quantitative drug loading. Here we show the detai...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Acta Pharmacol Sin
Prif Awduron: Cheetham, Andrew G, Lin, Yi-an, Lin, Ran, Cui, Honggang
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2017
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5520181/
https://ncbi.nlm.nih.gov/pubmed/28260797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2016.151
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