Supramolecular Crafting of Self-Assembling Camptothecin Prodrugs with Enhanced Efficacy against Primary Cancer Cells

Chemical modification of small molecule hydrophobic drugs is a clinically proven strategy to devise prodrugs with enhanced treatment efficacy. While this prodrug strategy improves the parent drug's water solubility and pharmacokinetic profile, it typically compromises the drug's potency ag...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Theranostics
Autori principali: Su, Hao, Zhang, Pengcheng, Cheetham, Andrew G, Koo, Jin Mo, Lin, Ran, Masood, Asad, Schiapparelli, Paula, Quiñones-Hinojosa, Alfredo, Cui, Honggang
Natura: Artigo
Lingua:Inglês
Pubblicazione: Ivyspring International Publisher 2016
Soggetti:
Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4876630/
https://ncbi.nlm.nih.gov/pubmed/27217839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.15420
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