Compromised BRCA1-PALB2 interaction is associated with breast cancer risk

The major breast cancer suppressor proteins BRCA1 and BRCA2 play essential roles in homologous recombination (HR)-mediated DNA repair, which is thought to be critical for tumor suppression. The two BRCA proteins are linked by a third tumor suppressor, PALB2, in the HR pathway. While truncating mutat...

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Pubblicato in:Oncogene
Autori principali: Foo, Tzeh Keong, Tischkowitz, Marc, Simhadri, Srilatha, Boshari, Talia, Zayed, Nadia, Burke, Kathleen A., Berman, Samuel H., Blecua, Pedro, Riaz, Nadeem, Huo, Yanying, Ding, Yuan Chun, Neuhausen, Susan L., Weigelt, Britta, Reis-Filho, Jorge S., Foulkes, William D., Xia, Bing
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5519427/
https://ncbi.nlm.nih.gov/pubmed/28319063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2017.46
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