The intracellular chloride channel proteins CLIC1 and CLIC4 induce IL-1β transcription and activate the NLRP3 inflammasome

The NLRP3 inflammasome is a multiprotein complex that regulates the activation of caspase-1 leading to the maturation of the proinflammatory cytokines IL-1β and IL-18 and promoting pyroptosis. Classically, the NLRP3 inflammasome in murine macrophages is activated by the recognition of pathogen-assoc...

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Bibliografische gegevens
Gepubliceerd in:J Biol Chem
Hoofdauteurs: Domingo-Fernández, Raquel, Coll, Rebecca C., Kearney, Jay, Breit, Samuel, O'Neill, Luke A. J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2017
Onderwerpen:
Immunology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5519359/
https://ncbi.nlm.nih.gov/pubmed/28576828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.797126
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