CLICs-dependent chloride efflux is an essential and proximal upstream event for NLRP3 inflammasome activation

The NLRP3 inflammasome can sense different pathogens or danger signals, and has been reported to be involved in the development of many human diseases. Potassium efflux and mitochondrial damage are both reported to mediate NLRP3 inflammasome activation, but the underlying, orchestrating signaling ev...

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Bibliografiske detaljer
Udgivet i:Nat Commun
Main Authors: Tang, Tiantian, Lang, Xueting, Xu, Congfei, Wang, Xiaqiong, Gong, Tao, Yang, Yanqing, Cui, Jun, Bai, Li, Wang, Jun, Jiang, Wei, Zhou, Rongbin
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5544706/
https://ncbi.nlm.nih.gov/pubmed/28779175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00227-x
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