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The Cytokine Release Inhibitory Drug CRID3 Targets ASC Oligomerisation in the NLRP3 and AIM2 Inflammasomes
BACKGROUND: The Inflammasomes are multi-protein complexes that regulate caspase-1 activation and the production of the pro-inflammatory cytokine IL-1β. Previous studies identified a class of diarylsulfonylurea containing compounds called Cytokine Release Inhibitory Drugs (CRIDs) that inhibited the p...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2011
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3245271/ https://ncbi.nlm.nih.gov/pubmed/22216309 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0029539 |
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