The Cytokine Release Inhibitory Drug CRID3 Targets ASC Oligomerisation in the NLRP3 and AIM2 Inflammasomes

BACKGROUND: The Inflammasomes are multi-protein complexes that regulate caspase-1 activation and the production of the pro-inflammatory cytokine IL-1β. Previous studies identified a class of diarylsulfonylurea containing compounds called Cytokine Release Inhibitory Drugs (CRIDs) that inhibited the p...

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Bibliographic Details
Main Authors: Coll, Rebecca C., O'Neill, Luke A. J.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2011
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3245271/
https://ncbi.nlm.nih.gov/pubmed/22216309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0029539
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