Autophagy inhibitor 3-methyladenine alleviates overload-exercise-induced cardiac injury in rats

Overload-exercise (OE) causes myocardial injury through inducing autophagy and apoptosis. In this study we examined whether an autophagy inhibitor 3-methyladenine (3-MA) could alleviate OE-induced cardiac injury. Rats were injected with 3-MA (15 mg/kg, iv) or saline before subjected to various inten...

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Bibliografski detalji
Izdano u:Acta Pharmacol Sin
Glavni autori: Liu, Hua, Lei, Hui, Shi, Yue, Wang, Jin-ju, Chen, Ning, Li, Zhang-hua, Chen, Yan-fang, Ye, Qi-fa, Yang, Yi
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2017
Teme:
Original Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5519243/
https://ncbi.nlm.nih.gov/pubmed/28260802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2016.169
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