Deacetylation of mycothiol-derived ‘waste product’ triggers the last biosynthetic steps of lincosamide antibiotics

The immediate post-condensation steps in lincomycin biosynthesis are reminiscent of the mycothiol-dependent detoxification system of actinomycetes. This machinery provides the last proven lincomycin intermediate, a mercapturic acid derivative, which formally represents the ‘waste product’ of the det...

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Publicat a:Chem Sci
Autors principals: Kamenik, Zdenek, Kadlcik, Stanislav, Radojevic, Bojana, Jiraskova, Petra, Kuzma, Marek, Gazak, Radek, Najmanova, Lucie, Kopecky, Jan, Janata, Jiri
Format: Artigo
Idioma:Inglês
Publicat: Royal Society of Chemistry 2016
Matèries:
Chemistry
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5518657/
https://ncbi.nlm.nih.gov/pubmed/28791100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5sc03327f
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