Lipophilic halogenated congeners of 2',3'-dideoxypurine nucleosides active against human immunodeficiency virus in vitro.

Four 2-amino-6-halo- and four 6-halo-2',3'-dideoxypurine ribofuranosides (ddPs) were synthesized and tested for in vitro activity to suppress the infectivity, cytopathic effect, Gag protein expression, and DNA synthesis of human immunodeficiency virus (HIV). The comparative order of in vit...

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Detalhes bibliográficos
Main Authors: Shirasaka, T, Murakami, K, Ford, H, Kelley, J A, Yoshioka, H, Kojima, E, Aoki, S, Broder, S, Mitsuya, H
Formato: Artigo
Idioma:Inglês
Publicado em: 1990
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC55178/
https://ncbi.nlm.nih.gov/pubmed/2251284
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