Pharmacokinetics of dideoxypurine nucleoside analogs in plasma and cerebrospinal fluid of rhesus monkeys.

The pharmacokinetics of 2',3'-dideoxyadenosine (ddA), didanosine, 2',3'-dideoxyguanosine (ddG), and 6-halogenated prodrugs of ddG, 6-chloro-ddG and 6-iodo-ddG, in plasma and cerebrospinal fluid (CSF) were studied in a non-human primate model. ddA was rapidly and completely deaminated to didanosine,...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Hawkins, M E, Mitsuya, H, McCully, C M, Godwin, K S, Murakami, K, Poplack, D G, Balis, F M
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1995
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC162723/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7574512/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.39.6.1259
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