Lipophilic halogenated congeners of 2',3'-dideoxypurine nucleosides active against human immunodeficiency virus in vitro.

Four 2-amino-6-halo- and four 6-halo-2',3'-dideoxypurine ribofuranosides (ddPs) were synthesized and tested for in vitro activity to suppress the infectivity, cytopathic effect, Gag protein expression, and DNA synthesis of human immunodeficiency virus (HIV). The comparative order of in vitro anti-HI...

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הוצא לאור ב:	Proc Natl Acad Sci U S A
Principais autores:	Shirasaka, T, Murakami, K, Ford, H, Kelley, J A, Yoshioka, H, Kojima, E, Aoki, S, Broder, S, Mitsuya, H
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	National Academy of Sciences 1990
נושאים:	Research Article
גישה מקוונת:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC55178/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2251284/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.23.9426
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