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Pharmacokinetics of the Protease Inhibitor KNI-272 in Plasma and Cerebrospinal Fluid in Nonhuman Primates after Intravenous Dosing and in Human Immunodeficiency Virus-Infected Children after Intravenous and Oral Dosing

KNI-272 is a human immunodeficiency virus (HIV) protease inhibitor with potent activity in vitro. We studied the pharmacokinetics of KNI-272 in the plasma and cerebrospinal fluid (CSF) of a nonhuman primate model and after intravenous and oral administration to children with HIV infection. Plasma an...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Mueller, Brigitta U., Anderson, Barry D., Farley, Maureen Q., Murphy, Robert, Zuckerman, Judy, Jarosinski, Paul, Godwin, Karen, McCully, Cindy L., Mitsuya, Hiroaki, Pizzo, Philip A., Balis, Frank M.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society for Microbiology 1998
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC105689/
https://ncbi.nlm.nih.gov/pubmed/9661027
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