Metabolic Reprogramming, Autophagy, and Reactive Oxygen Species Are Necessary for Primordial Germ Cell Reprogramming into Pluripotency

Cellular reprogramming is accompanied by a metabolic shift from oxidative phosphorylation (OXPHOS) toward glycolysis. Previous results from our laboratory showed that hypoxia alone is able to reprogram primordial germ cells (PGCs) into pluripotency and that this action is mediated by hypoxia-inducib...

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Detalhes bibliográficos
Publicado no:Oxid Med Cell Longev
Main Authors: Sainz de la Maza, D., Moratilla, A., Aparicio, V., Lorca, C., Alcaina, Y., Martín, D., De Miguel, M. P.
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5516724/
https://ncbi.nlm.nih.gov/pubmed/28757909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2017/4745252
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