Metabolic Reprogramming, Autophagy, and Reactive Oxygen Species Are Necessary for Primordial Germ Cell Reprogramming into Pluripotency

Cellular reprogramming is accompanied by a metabolic shift from oxidative phosphorylation (OXPHOS) toward glycolysis. Previous results from our laboratory showed that hypoxia alone is able to reprogram primordial germ cells (PGCs) into pluripotency and that this action is mediated by hypoxia-inducib...

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Библиографические подробности
Опубликовано в: :Oxid Med Cell Longev
Главные авторы: Sainz de la Maza, D., Moratilla, A., Aparicio, V., Lorca, C., Alcaina, Y., Martín, D., De Miguel, M. P.
Формат: Artigo
Язык:Inglês
Опубликовано: Hindawi 2017
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5516724/
https://ncbi.nlm.nih.gov/pubmed/28757909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2017/4745252
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