Metabolic Reprogramming, Autophagy, and Reactive Oxygen Species Are Necessary for Primordial Germ Cell Reprogramming into Pluripotency

Cellular reprogramming is accompanied by a metabolic shift from oxidative phosphorylation (OXPHOS) toward glycolysis. Previous results from our laboratory showed that hypoxia alone is able to reprogram primordial germ cells (PGCs) into pluripotency and that this action is mediated by hypoxia-inducib...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Oxid Med Cell Longev
Prif Awduron: Sainz de la Maza, D., Moratilla, A., Aparicio, V., Lorca, C., Alcaina, Y., Martín, D., De Miguel, M. P.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Hindawi 2017
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5516724/
https://ncbi.nlm.nih.gov/pubmed/28757909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2017/4745252
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