L-2-hydroxyglutarate production arises from non-canonical enzyme function at acidic pH

The metabolite 2-hydroxyglutarate (2HG) can be produced as either a D(R)- or L(S)- enantiomer, each of which inhibits alpha-ketoglutarate (αKG)-dependent enzymes involved in diverse biologic processes. Oncogenic mutations in isocitrate dehydrogenase produce D-2HG, which causes a pathologic blockade...

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Publicado no:Nat Chem Biol
Main Authors: Intlekofer, Andrew M., Wang, Bo, Liu, Hui, Shah, Hardik, Carmona-Fontaine, Carlos, Rustenburg, Ariën S., Salah, Salah, Gunner, M. R., Chodera, John D., Cross, Justin R., Thompson, Craig B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5516644/
https://ncbi.nlm.nih.gov/pubmed/28263965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2307
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