Hypoxia Induces Production of L-2-Hydroxyglutarate

Somatic mutations in isocitrate dehydrogenase 1 or 2 (IDH1/2) contribute to the pathogenesis of cancer via production of the ‘oncometabolite’ D-2-hydroxyglutarate (D-2HG). Elevated D-2HG can block differentiation of malignant cells by functioning as a competitive inhibitor of alpha-ketoglutarate (α-...

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Bibliografske podrobnosti
izdano v:Cell Metab
Main Authors: Intlekofer, Andrew M., Dematteo, Raymond G., Venneti, Sriram, Finley, Lydia W. S., Lu, Chao, Judkins, Alexander R., Rustenburg, Ariën S., Grinaway, Patrick B., Chodera, John D., Cross, Justin R., Thompson, Craig B.
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4527873/
https://ncbi.nlm.nih.gov/pubmed/26212717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2015.06.023
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