Hypoxia Induces Production of L-2-Hydroxyglutarate

Somatic mutations in isocitrate dehydrogenase 1 or 2 (IDH1/2) contribute to the pathogenesis of cancer via production of the ‘oncometabolite’ D-2-hydroxyglutarate (D-2HG). Elevated D-2HG can block differentiation of malignant cells by functioning as a competitive inhibitor of alpha-ketoglutarate (α-...

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Udgivet i:Cell Metab
Main Authors: Intlekofer, Andrew M., Dematteo, Raymond G., Venneti, Sriram, Finley, Lydia W. S., Lu, Chao, Judkins, Alexander R., Rustenburg, Ariën S., Grinaway, Patrick B., Chodera, John D., Cross, Justin R., Thompson, Craig B.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4527873/
https://ncbi.nlm.nih.gov/pubmed/26212717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2015.06.023
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