Hypoxia Induces Production of L-2-Hydroxyglutarate

Somatic mutations in isocitrate dehydrogenase 1 or 2 (IDH1/2) contribute to the pathogenesis of cancer via production of the ‘oncometabolite’ D-2-hydroxyglutarate (D-2HG). Elevated D-2HG can block differentiation of malignant cells by functioning as a competitive inhibitor of alpha-ketoglutarate (α-...

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Detalhes bibliográficos
Publicado no:Cell Metab
Main Authors: Intlekofer, Andrew M., Dematteo, Raymond G., Venneti, Sriram, Finley, Lydia W. S., Lu, Chao, Judkins, Alexander R., Rustenburg, Ariën S., Grinaway, Patrick B., Chodera, John D., Cross, Justin R., Thompson, Craig B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4527873/
https://ncbi.nlm.nih.gov/pubmed/26212717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2015.06.023
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