Central nervous system uptake of intranasal glutathione in Parkinson’s disease

Glutathione (GSH) is depleted early in the course of Parkinson’s disease (PD), and deficiency has been shown to perpetuate oxidative stress, mitochondrial dysfunction, impaired autophagy, and cell death. GSH repletion has been proposed as a therapeutic intervention. The objective of this study was t...

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Vydáno v:NPJ Parkinsons Dis
Hlavní autoři: Mischley, Laurie K, Conley, Kevin E, Shankland, Eric G, Kavanagh, Terrance J, Rosenfeld, Michael E, Duda, John E, White, Collin C, Wilbur, Timothy K, De La Torre, Prysilla U, Padowski, Jeannie M
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5516583/
https://ncbi.nlm.nih.gov/pubmed/28725693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npjparkd.2016.2
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