A Nonredundant Phosphopantetheinyl Transferase, PptA, Is a Novel Antifungal Target That Directs Secondary Metabolite, Siderophore, and Lysine Biosynthesis in Aspergillus fumigatus and Is Critical for Pathogenicity

Secondary metabolites are key mediators of virulence for many pathogens. Aspergillus fumigatus produces a vast array of these bioactive molecules, the biosynthesis of which is catalyzed by nonribosomal peptide synthetases (NRPSs) or polyketide synthases (PKSs). Both NRPSs and PKSs harbor carrier dom...

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Detalhes bibliográficos
Publicado no:mBio
Main Authors: Johns, Anna, Scharf, Daniel H., Gsaller, Fabio, Schmidt, Hella, Heinekamp, Thorsten, Straßburger, Maria, Oliver, Jason D., Birch, Mike, Beckmann, Nicola, Dobb, Katharine S., Gilsenan, Jane, Rash, Bharatkumar, Bignell, Elaine, Brakhage, Axel A., Bromley, Michael J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5516258/
https://ncbi.nlm.nih.gov/pubmed/28720735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01504-16
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