A Nonredundant Phosphopantetheinyl Transferase, PptA, Is a Novel Antifungal Target That Directs Secondary Metabolite, Siderophore, and Lysine Biosynthesis in Aspergillus fumigatus and Is Critical for Pathogenicity

Secondary metabolites are key mediators of virulence for many pathogens. Aspergillus fumigatus produces a vast array of these bioactive molecules, the biosynthesis of which is catalyzed by nonribosomal peptide synthetases (NRPSs) or polyketide synthases (PKSs). Both NRPSs and PKSs harbor carrier dom...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:mBio
Asıl Yazarlar: Johns, Anna, Scharf, Daniel H., Gsaller, Fabio, Schmidt, Hella, Heinekamp, Thorsten, Straßburger, Maria, Oliver, Jason D., Birch, Mike, Beckmann, Nicola, Dobb, Katharine S., Gilsenan, Jane, Rash, Bharatkumar, Bignell, Elaine, Brakhage, Axel A., Bromley, Michael J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2017
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5516258/
https://ncbi.nlm.nih.gov/pubmed/28720735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01504-16
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller