Mechanistic Basis of pH-Dependent 5-Flucytosine Resistance in Aspergillus fumigatus

The antifungal drug 5-flucytosine (5FC), a derivative of the nucleobase cytosine, is licensed for the treatment of fungal diseases; however, it is rarely used as a monotherapeutic to treat Aspergillus infection. Despite being potent against other fungal pathogens, 5FC has limited activity against As...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Gsaller, Fabio, Furukawa, Takanori, Carr, Paul D., Rash, Bharat, Jöchl, Christoph, Bertuzzi, Margherita, Bignell, Elaine M., Bromley, Michael J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2018
Témata:
Mechanisms of Resistance
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5971587/
https://ncbi.nlm.nih.gov/pubmed/29610197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02593-17
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