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Cell-type specific differences in promoter activity of the ALS-linked C9orf72 mouse ortholog

A hexanucleotide repeat expansion in the C9orf72 gene is the most common cause of inherited forms of the neurodegenerative disease amyotrophic lateral sclerosis (ALS). Both loss-of-function and gain-of-function mechanisms have been proposed to underlie this disease, but the pathogenic pathways are n...

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Bibliografiska uppgifter
I publikationen:Sci Rep
Huvudupphovsmän: Langseth, Abraham J., Kim, Juhyun, Ugolino, Janet E., Shah, Yajas, Hwang, Ho-Yon, Wang, Jiou, Bergles, Dwight E., Brown, Solange P.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group UK 2017
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5515847/
https://ncbi.nlm.nih.gov/pubmed/28720882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-05864-2
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