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Extracellular cyclophilin A, especially acetylated, causes pulmonary hypertension by stimulating endothelial apoptosis, redox stress and inflammation
OBJECTIVE: Oxidative stress and inflammation play key roles in development of pulmonary arterial hypertension (PAH). Cyclophilin A (CypA) is secreted in response to oxidative stress, and promotes inflammation and cardiovascular disease. Endothelial cell (EC) dysfunction is an early event in the path...
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| Publicado en: | Arterioscler Thromb Vasc Biol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2017
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5515294/ https://ncbi.nlm.nih.gov/pubmed/28450293 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.117.309212 |
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