Polymorphisms in methotrexate transporters and their relationship to plasma methotrexate levels, toxicity of high-dose methotrexate, and outcome of pediatric acute lymphoblastic leukemia

High-dose methotrexate (HDMTX) plays an important role in the treatment of acute lymphoblastic leukemia (ALL) although there is great inter-patient variability in the efficacy and toxicity of MTX. The relationship between polymorphisms in genes encoding MTX transporters and MTX response is controver...

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Publicado en:Oncotarget
Autores principales: Liu, Shu-Guang, Gao, Chao, Zhang, Rui-Dong, Zhao, Xiao-Xi, Cui, Lei, Li, Wei-Jing, Chen, Zhen-Ping, Yue, Zhi-Xia, Zhang, Yuan-Yuan, Wu, Min-Yuan, Wang, Jian-Xiang, Li, Zhi-Gang, Zheng, Hu-Yong
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5514947/
https://ncbi.nlm.nih.gov/pubmed/28525903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.17781
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