FPGS rs1544105 polymorphism is associated with treatment outcome in pediatric B-cell precursor acute lymphoblastic leukemia

BACKGROUND: Folypolyglutamate synthase (FPGS) catalyzes the polyglutamation of folates and antifolates, such as methotrexate (MTX), to produce highly active metabolites. FPGS tag SNP rs1544105C > T is located in the gene promoter. The aim of the present study was to investigate the impact of rs15...

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Autori principali: Liu, Shu-Guang, Gao, Chao, Zhang, Rui-Dong, Jiao, Ying, Cui, Lei, Li, Wei-Jing, Chen, Zhen-Ping, Wu, Min-Yuan, Zheng, Hu-Yong, Zhao, Xiao-Xi, Yue, Zhi-Xia, Li, Zhi-Gang
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2013
Soggetti:
Primary Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3819686/
https://ncbi.nlm.nih.gov/pubmed/24168269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2867-13-107
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