CCND1 G870A polymorphism is associated with toxicity of methotrexate in childhood acute lymphoblastic leukemia

CCND1 plays a key role in cell cycle progression and may cause methotrexate (MTX) resistance, as well as its cytotoxicity. CCND1 870A variant allele is associated with altered transcripts of this gene. We hypothesized that this polymorphism may contribute to the elimination rate and hepatotoxicity o...

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Vydáno v:Int J Clin Exp Pathol
Hlavní autoři: Xue, Yao, Rong, Liucheng, Tong, Na, Wang, Meilin, Zhang, Zhengdong, Fang, Yongjun
Médium: Artigo
Jazyk:Inglês
Vydáno: e-Century Publishing Corporation 2015
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4637712/
https://ncbi.nlm.nih.gov/pubmed/26617896
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