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CCND1 G870A polymorphism is associated with toxicity of methotrexate in childhood acute lymphoblastic leukemia
CCND1 plays a key role in cell cycle progression and may cause methotrexate (MTX) resistance, as well as its cytotoxicity. CCND1 870A variant allele is associated with altered transcripts of this gene. We hypothesized that this polymorphism may contribute to the elimination rate and hepatotoxicity o...
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| Pubblicato in: | Int J Clin Exp Pathol |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
e-Century Publishing Corporation
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4637712/ https://ncbi.nlm.nih.gov/pubmed/26617896 |
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