MTHFR polymorphisms in childhood acute lymphoblastic leukemia: influence on methotrexate therapy

Methotrexate (MTX) is an important component in the therapy used to treat childhood acute lymphoblastic leukemia (ALL). Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme for MTX pharmacokinetics. Two single-nucleotide polymorphisms in MTHFR gene, C677T and A1298C, affecting MTHFR activity,...

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Detalhes bibliográficos
Publicado no:Pharmgenomics Pers Med
Main Authors: Umerez, Maitane, Gutierrez-Camino, Ángela, Muñoz-Maldonado, Carmen, Martin-Guerrero, Idoia, Garcia-Orad, Africa
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2017
Assuntos:
Review
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5376125/
https://ncbi.nlm.nih.gov/pubmed/28392709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/PGPM.S107047
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