Association of ABCC2 −24C>T Polymorphism with High-Dose Methotrexate Plasma Concentrations and Toxicities in Childhood Acute Lymphoblastic Leukemia

Methotrexate (MTX) is a key agent for the treatment of childhood acute lymphoblastic leukemia (ALL). Increased MTX plasma concentrations are associated with a higher risk of adverse drug effects. ATP-binding cassette subfamily C member 2 (ABCC2) is important for excretion of MTX and its toxic metabo...

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Detalhes bibliográficos
Main Authors: Liu, Yan, Yin, You, Sheng, Qi, Lu, Xiaotong, Wang, Fang, Lin, Zhiyan, Tian, Huaiping, Xu, Ajing, Zhang, Jian
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3880259/
https://ncbi.nlm.nih.gov/pubmed/24404132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0082681
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