IKK inhibition by BMS-345541 suppresses breast tumorigenesis and metastases by targeting GD2(+) cancer stem cells

We have identified that the ganglioside GD2 is a marker for breast cancer stem cells (BCSCs), and that targeting the enzyme GD3 synthase (GD3S, which regulates GD2 biosynthesis) reduces breast tumorigenesis. The pathways regulating GD2 expression, and their anomalous functions in BCSC, are unclear....

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Bibliographische Detailangaben
Veröffentlicht in:Oncotarget
Hauptverfasser: Battula, Venkata Lokesh, Nguyen, Khoa, Sun, Jeff, Pitner, Mary Kathryn, Yuan, Bin, Bartholomeusz, Chandra, Hail, Numsen, Andreeff, Michael
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2017
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Priority Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5514883/
https://ncbi.nlm.nih.gov/pubmed/28415808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16294
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